Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSRYQCSLCQLETLENDLNFCVCCRAAVCAKCTLACYPNRKSVGLCVRCTPPDYGFACGRCRRHISYGDIEFFCDMCAVPICFTCVASGTSFECGQLKCSLCCECPMSQAPRNLVVRHEVDDAMLRQLPIPLVSSATPLAAPPPQARAAAAAVAATKSTKYRKLFGREKLGEGAQGVVYKCHTE-ENEVVVVKEMVFNDTDVTAFEAQA-RQVERMRQLNHPHLIRYLDVSVQKDPLRICVVMPFYSEGDLKKFIERQRKPVTEVKLC-SIVLQIAGALNYLHRQEPPLVHRDIKPENILLLNHEEQVLLMDLDLCRTVDVTASVIKRRELSPTYEYRAPELEKS--HGDTKADVFSLGVVMFVLATLPDFPCVRTDSGEMLVFSASKWSPSSLKRAIQREIRRVQRYTYSEEFIRLVVAMLVHQPAARPTSGAVIYRLQKIMEQRLMEGKE 4EON Chain:A ((10-200)) -----------------------------------------------------------------------------------------------------------------------------------------------------------------------EKIGEGTYGVVYKARNKLTGEVVALKKIRL-DTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTEN--KLYLVFEFLSM-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR--VLHRDLKPEN-LLINTEGAIKLADFGLARAFGVPVRTYTHEVV--TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-------------------------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 4EON.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 834 -12023 -14.42 -64.64 target 2D structure prediction score : 0.70 Monomeric hydrophicity matching model chain A : 0.63 3D Compatibility (PKB) : -14.42 2D Compatibility (Sec. Struct. Predict.) : 0.70 1D Compatibility (Hydrophobicity) : 0.63 QMean score : 0.502

(partial model without unconserved sides chains): PDB file : Tito_4EON.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4EON-query.scw PDB file : Tito_Scwrl_4EON.pdb: