Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKIIVIGQSGSGKSTLARKIKEITDFPLLPLDLLWHTTDYSIQAKKWFLQEQQLFMVSNPSWIVEGNYTSTLEERIKEADKIIWLKVPRYLAIYRVVW-----------RSLKRKINKKS-RPDMPESFS---EK--LNREYLEFLSFIWHFEENNEPKIQQLIQVAN--ARNKLIILKTRREKQEFLTKLKIESKNN 4MYC Chain:C ((463-645)) WKTAIVGSSGSGKSTILKLVFRFYDP--ESGRILINGRDIKEYDIDALRKVI-GVVPQ-DTPLFNDTIWENVKFGRIDATDEEVITVVEKAQLAPLIKKLPQGFDTIVGERGLMISGGEKQRLAIARVLLKNARIMFFDEAT-------SALDTHTEQALLRTIRDNFTSGSRTSVYIAHRLRTIADADKIIVL----

General information: TITO was launched using: RESULT: Template: 4MYC.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain C - contact count / total energy / energy per contact / energy per residue : 649 -7339 -11.31 -44.75 target 2D structure prediction score : 0.45 Monomeric hydrophicity matching model chain C : 0.63 3D Compatibility (PKB) : -11.31 2D Compatibility (Sec. Struct. Predict.) : 0.45 1D Compatibility (Hydrophobicity) : 0.63 QMean score : 0.171

(partial model without unconserved sides chains): PDB file : Tito_4MYC.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4MYC-query.scw PDB file : Tito_Scwrl_4MYC.pdb: