Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSQLSDINQMNMTTANTARLLITCEDKPGIVQAVSSFLYHQGANITALDQYATEAQGGRYFMRVEFELDHL-QSRKDALIQTFAAN-VAERYGMQWRLAFVNDIKKVGILVSKVDHALLELLWRHARGSLPCEITHVISNHEDLREAVENFGILFTVIKVTKDNKAEAYAQIHEMMQ--GNDLLVLARYMQILSEDFVSKWEMKIINIHHSFLPAFVGANPYKQAYEKGVKLIGATAHYVTADLDQGPIIEQDVERVSHDYNVEQLRELGEDVERNVLARAVKWHLEDRIIVDGNKTVVF 3W7B Chain:A ((2-284)) ---------------EEARLLVTCPDRPGIVAAVSGFLYAHGANITDLQQHSTDPEGGTFFMRVAFTASHLDL-ARPALERAFQ-EVVASRFQMQWRLAYASERKRTAILVSKPAHALLELLWRYRVGELPMELRLVISNHPDHREEVERFGIPYHHVPVEKGRKEEAEERILALLEAEGVELVVLARYMQILSPGFVERFPMRIINIHHSFLPAFAGADPYRQAYERGVKLIGATAHYVTEELDQGPIIEQDVVRVSHRHSVREMKRLGRELERTVLARAVRWHLEDRILVHENRTVVF

General information: TITO was launched using: RESULT: Template: 3W7B.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1334 -84838 -63.60 -304.08 target 2D structure prediction score : 0.62 Monomeric hydrophicity matching model chain A : 0.85 3D Compatibility (PKB) : -63.60 2D Compatibility (Sec. Struct. Predict.) : 0.62 1D Compatibility (Hydrophobicity) : 0.85 QMean score : 0.565

(partial model without unconserved sides chains): PDB file : Tito_3W7B.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3W7B-query.scw PDB file : Tito_Scwrl_3W7B.pdb: