Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVG-----------DTGTIGERYGAVVKK----------------HDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI 1HVY Chain:C ((1-288)) PPHGELQYLGQIQHILRCGVRKDDRT-----GT--GTLSVFGMQARYSLRD-EFPLLTTKRVFWKGVLEELLWFIKGST-NAKELS-SKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPR-DLPLMALPPCHALCQFYVV--N--SELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPF-PKLRILR-KVEKIDDFKAEDFQIEGYNP-HPTIKMEMAV

General information: TITO was launched using: RESULT: Template: 1HVY.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain C - contact count / total energy / energy per contact / energy per residue : 1305 448 0.34 1.72 target 2D structure prediction score : 0.63 Monomeric hydrophicity matching model chain C : 0.72 3D Compatibility (PKB) : 0.34 2D Compatibility (Sec. Struct. Predict.) : 0.63 1D Compatibility (Hydrophobicity) : 0.72 QMean score : 0.524

(partial model without unconserved sides chains): PDB file : Tito_1HVY.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1HVY-query.scw PDB file : Tito_Scwrl_1HVY.pdb: