Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence ---------------------MRGIKMNSSIDQDPNRTLTLILYVLYIVAIFTGGLLAIIALIINYVKRSDVQGSIFASHFTWQIRTFWWYLAWNIIA---------FLPFIFLFFTGENTDLFAGVAISSTV--------FCVGVIAAAWIWIVYRAIRGLIALNDNRPMYQP----- 1CD3 Chain:G ((1-175)) MFQTFISRHNSNFFSDKLVLTSVTPASSAPVLQTPKATSSTLYFDSLTVNAG--NGGFLHCIQMDTSVNAANQVVSVGADIAFDADPKFFACLVRFESSSVPTTLPTAYDVYPLNGRHDGGYYTVKDCVTIDVLPRTPGNNVYVGFMVWSN-F-TATKCRGLVSLNQVIKEIICLQPLK

General information: TITO was launched using: RESULT: Template: 1CD3.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain G - contact count / total energy / energy per contact / energy per residue : 509 -57658 -113.28 -436.80 target 2D structure prediction score : 0.36 Monomeric hydrophicity matching model chain G : 0.63 3D Compatibility (PKB) : -113.28 2D Compatibility (Sec. Struct. Predict.) : 0.36 1D Compatibility (Hydrophobicity) : 0.63 QMean score : 0.055

(partial model without unconserved sides chains): PDB file : Tito_1CD3.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1CD3-query.scw PDB file : Tito_Scwrl_1CD3.pdb: