Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEKFVDDHHLKRKVGTLEMVVAMLLSGSIGLFVIKSGQSPINIVFFRCLISALCLIPICYFYGHFRKVYFGKKELFLMVTSGLLIIFNWVLLFAAFPKTSISLATIVYHVNPFVILFLGALVFHEKLNKNDVLWTIIAFIGLIVIIGLGSASVNSNELVGLGLVLIATTLYSISVLITKKLSNTPPLLIVFIQTLSGAIVMAPFISVFENPPIGQQWLFVVGLGVLHTAFLYYLMYSAIKKIPLNNIAILSFIYPISTIVIDYFFFDHVLTSTQVLGAGLILLGVLGVKLHWNIFAVKKVGIRN 1CDL Chain:E ((2-20)) RRKWQKTGHAVRAIGRLSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 1CDL.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain E - contact count / total energy / energy per contact / energy per residue : 2 -55 -27.50 -2.89 target 2D structure prediction score : 0.58 Monomeric hydrophicity matching model chain E : 0.34 3D Compatibility (PKB) : -27.50 2D Compatibility (Sec. Struct. Predict.) : 0.58 1D Compatibility (Hydrophobicity) : 0.34 QMean score : 0.505

(partial model without unconserved sides chains): PDB file : Tito_1CDL.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1CDL-query.scw PDB file : Tito_Scwrl_1CDL.pdb: