Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKKIEPIPPSLPLLTKGEFYLEDEEIFSGLLINGGDQSYLDAKNMVLRESHIQKLTMQKTVLRHFECSNVIFEKCDF--SNLEWIG---GSFHQVVFHQCKLTGTNFAESYLRDC------TFTDCIASMASFSSTNLKAVSFDHCQLEDSEFYEVTWKNLFLSDNQLTGSNWFRTSLKGLDFTTNFFTAIALSQDSLAGLIVNQEQALVIAQALGLQIKD 2XT2 Chain:A ((20-199)) ----------------------------------------DRSGQSLESIRFEDCTFRQCNFTEAELNRCKFRECEFVDCNLSLISIPQTSFMEVRFVDCKMLGVNWTSAQWPSVKMEGALSFERCILNDSLFYGLYLAGVKMVECRIHDANFTEADCEDADFTQSDLKGSTFHNTKLTGASFIDAVNYHIDIFHNDIKRARFSLPEAASLLNSLDIELS-

General information: TITO was launched using: RESULT: Template: 2XT2.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 990 -38864 -39.26 -229.96 target 2D structure prediction score : 0.36 Monomeric hydrophicity matching model chain A : 0.68 3D Compatibility (PKB) : -39.26 2D Compatibility (Sec. Struct. Predict.) : 0.36 1D Compatibility (Hydrophobicity) : 0.68 QMean score : 0.289

(partial model without unconserved sides chains): PDB file : Tito_2XT2.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2XT2-query.scw PDB file : Tito_Scwrl_2XT2.pdb: