Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTPGSVFFDQQFSFHDGE-SGEKLFVILGWD--N---GIAIVAKTTSQQHGRGTTFGCQPKDRFHNFYLPQNSCYFRKCTWVCLDEFYELNAV-EVLQKRFSGLINPVCNLTNEMLRKLQDCALESDDLSGRQESIIRSSLV 2C06 Chain:B ((1-107)) MERGEIWLVSLDPTAGHEQQGTRPVLIVTPAAFNRVTRLPVVVPVTSGGNFARTAG----------FAVSLDGVGIRTTGVVRCDQPRTIDMKARGG--------KRLERVPETIMNEVLGRLST-----------------

General information: TITO was launched using: RESULT: Template: 2C06.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain B - contact count / total energy / energy per contact / energy per residue : 441 -10487 -23.78 -104.87 target 2D structure prediction score : 0.53 Monomeric hydrophicity matching model chain B : 0.68 3D Compatibility (PKB) : -23.78 2D Compatibility (Sec. Struct. Predict.) : 0.53 1D Compatibility (Hydrophobicity) : 0.68 QMean score : 0.380

(partial model without unconserved sides chains): PDB file : Tito_2C06.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2C06-query.scw PDB file : Tito_Scwrl_2C06.pdb: