Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MQRNHICNIGGKNVGKPIISFDQVVKRYDDETVLKKVSFEIEQGKFYTLLGPSGCGKTTILRIIAGFTEATEGDIYFEGKRLNDLPANKRQVNTVFQDYALFPHMNVFDNVAFGLKIKKMSKSDIEKKVKDALRMVQLPGYEKREISEMSGGQRQRVAIARAIVNEPKVLLLDEPLSALDLKLRTDMQYELRDLQQRLGITFIFVTHDQEEALAMSDEIFVMNKGKIVQSGTPVDIYDEPINHFVADFVGESN--IVDGVMIEDNLVEFVGKQFE---CV-DGGMRLNEPVEVVLRPEDLTITTPD----KGKLVVTVDTQLFRGVHYEIICYDEQQNEWMVHS--TKKAKEGSKVGLAFEPEDIHVMRFNESEEEFDARLDSYEE 1V43 Chain:A ((10-371)) ---------------MVEVKLENLTKRFGNFTAVNKLNLTIKDGEFLVLLGPSGCGKTTTLRMIAGLEEPTEGRIYFGDRDVTYLPPKDRNISMVFQ------HMTVYENIAFPL--KKFPKDEIDKRVRWAAELLQIEELLNRYPAQLSGGQRQRVAVARAIVVEPDVLLMDEPLSNLDAKLRVAMRAEIKKLQQKLKVTTIYVTHDQVEAMTMGDRIAVMNRGQLLQIGSPTEVYLRPNSVFVATFIGAPEMNILEVSVGDGYL-EGRGFRIELPQ-MDLLKDYVGKTVLFGIRPEHMTVEGV-HMKRTARLIGKVDFVEALGTDTILHV-KFGDELVKVKLPGHIPIEPGREVKVIMDLDMIHVFDKDTEKA-----------

General information: TITO was launched using: RESULT: Template: 1V43.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1732 -132209 -76.33 -393.48 target 2D structure prediction score : 0.65 Monomeric hydrophicity matching model chain A : 0.78 3D Compatibility (PKB) : -76.33 2D Compatibility (Sec. Struct. Predict.) : 0.65 1D Compatibility (Hydrophobicity) : 0.78 QMean score : 0.543

(partial model without unconserved sides chains): PDB file : Tito_1V43.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1V43-query.scw PDB file : Tito_Scwrl_1V43.pdb: