Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERR-KDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVI-IPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFRE---ANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQ--GTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC 5DLQ Chain:A ((9-1107)) PEVIAQLENAAKVL---------------MAPPSMV--------SNEQRQHAEHIFLSFRKSKSPFAVCRHILETSKVDYVLFQAATAIMEAVVR----------------------------EWVLLEKGSIESLRTFLLTYVLQRPNLQKYVREQILLAVAVIVKR-GSLDKSIDCK-------SIFHEVSQLISSGNPTVQTLACSILTALLSEFSSFHGNCKRVFQE-EDLRQIFMLTVGVLQEFSRREN-LSAQMSSVFQRYLALANQVLSWNFLPPTESWREALLDSRVMELFFTVHRKIREDSDMAQDSLQCLAQLA----------------SLHGPIFPDEGSQVDYLAHFIEGLLNTINGIEIEDS------------EAVGISSIISNLITVFPRNVLT-------------------------------AIPSELFSSFVNCLTHLTCSFGRSAALEEVLDDMVYMEAYDKLLESWLTLVRDDKGFFTQHAVQVFNSYIQC---HLAAPDGTRNLTEEEISELQEDDRDQF----------------------SDQLASVGMLGRIAAEHCMPLLTSLLEERVTRM--------------LDDLYEDIHWLILVTGYLL--------ADDTQTPLIPPEIMEYSIKHSSEVDINTTLQILGSPGEKASSIPGYSR---------TDSVIRLLSAVLRVSEVESRAIRADL-THLLSPQMGKDIVWFLKRWAKTYLL-----VDEKLYDQISLPLSTAFGADT---------EGSQWIIGYLLQKVISNLSVWSSEQDLANDTVQLLVTLVE-------RRERANLVIQCENWWNLAKQFASRSPPLNFLSSPVQRTLMKALVLGGF--------------WTEVLQPLQQRFLRVIQQMCQQ---------EEVKQEITATLEALCGIAEATDNVAI-----LFNFLMDFLNNCIGLMEVYKNTPETVNLIIEVFVEVAHKQICYLGESKAMHLYEACLTLLQVYSKNNLGRQR--------------IDVTAEEEQYQDLLLIMELLTNLLA---------------DVVLYGVNLILPLMSQ-------------DLLKFPTLCN--QYYKLITFICE------IFPEKIPQL---------------LFKSLMYSLELGMTSMS---------SEVCQLCLEALTPLAFLATRHFLKLVFDMLVTTAAGEAFYTLVCQAEYSELVETLLSSQQDPVIYQRLADAFNKLTASSK--MAFLKSLEEFMANVG

General information: TITO was launched using: RESULT: Template: 5DLQ.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 4442 -197246 -44.40 -202.10 target 2D structure prediction score : 0.64 Monomeric hydrophicity matching model chain A : 0.64 3D Compatibility (PKB) : -44.40 2D Compatibility (Sec. Struct. Predict.) : 0.64 1D Compatibility (Hydrophobicity) : 0.64 QMean score : 0.312

(partial model without unconserved sides chains): PDB file : Tito_5DLQ.pdb: (Unconserved sides chains are recalculated) : Sequence: align-5DLQ-query.scw PDB file : Tito_Scwrl_5DLQ.pdb: