Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MQDDISGWTEW-NAHFEGIEEISSPSELHGLLTGIVCVTEAPTLEEWTQILTTL--NVPELNEEALALLTDEAEDVAHALSEDELDYLPMLPDDEHLLQDRVQALSDWCAGVVLGFGLASGHVRT---DERELIEHLQDVAAVEFEDSDNDEEGESSYEELYEFVRLIP-VSLSIGRKKVTVAESSLLKNFYAKSKTSTVGTADQNIVEMFTPHRPS 1IZM Chain:A ((2-171)) -----LISHSDMNQQLKSAGIGFNATELHGFLSGLLCG--GLKDQSWLPLLYQFSNDNHAYPTGLVQPVTELYEQISQTLSDVEGFTFELGLTEDENVFTQADSLSDWANQFLLGIGLAQPELAKEKGEIGEAVDDLQDICQLGYDEDDNEEELAEALEEIIEYVRTIAML---------------FYSHFN-------------------------

General information: TITO was launched using: RESULT: Template: 1IZM.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 639 20528 32.13 125.94 target 2D structure prediction score : 0.78 Monomeric hydrophicity matching model chain A : 0.72 3D Compatibility (PKB) : 32.13 2D Compatibility (Sec. Struct. Predict.) : 0.78 1D Compatibility (Hydrophobicity) : 0.72 QMean score : 0.522

(partial model without unconserved sides chains): PDB file : Tito_1IZM.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1IZM-query.scw PDB file : Tito_Scwrl_1IZM.pdb: