Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTMPKRQRSDEKAAHHVQLSVESGSRFDAYIRGWMQGTVEQPLLRPSLLPPLTPLPTLAAPSKSGAAQTPATASAATTVGDLSRLCEWTPPSAVMPASRTAVVYDTSMLDHVSPDAGDYERPARLQSTLDHLTVIGLLPCCQRIPARTAKKHELRRVHCRELIDTVDQLDFFMGIQE--G-RGSVIGQDLFASEHTSRAARMAAGCVIEAVKAVLSGAATNAFAIVRPPG--HHAGPANAAGYCLYNNVAVAARAAQAELAAAQAEHNPAGDAQQPRILILDWDVHHCDGTESIFYDDPSVLVISLHQYGNGHGHVLRKVSSAAAKNPAEISTPSKEAITADDLAALLSGGAIEPPPVSAPEASRPEAASDPPQGSTEGRRVRAAVDYNSLAAQIEEEGDAEIAALFGVDLNAASTSSSNSSSASTSSSVSADSTSVARNGTRPVHYAGDTVGVSFDETPRQRATGAEEEELFYPG-TGHLNRVGGDATPAAQGRNINIPWPTHGMGDLEYLQLLHEVVLPAAREFRPELVLISCGFDSASGDLLGSMCLTPSGYYIMTRLMAQNFPKLVVALEGGYNVRNVALCSEAVMRALLESSGCPGDRLPKSRMLWCQASSLVADIKRMHAPYWSCFSPNM 1C3R Chain:A ((2-320)) -------------------------------------------------------------------------------------------------KKVKLIGTLDYGKYRYP-KNHPLKIPRVSLLLRFKDAMNLIDEKELIKSRPATKEELLLFHTEDYINTLMEAERSQSVPKGAREKYNIGGYENPVSYAMFTGSSLATGSTVQAIEEFLKGN--VA---FNPAGGMHHAFKSRANGFCYINNPAVGIEYLRKK--------------GFKRILYIDLDAHHCDGVQEAFYDTDQVFVLSLHQSP----------------------------------------------------------------------------------------------------------------------------------------------------------------EYAFPFEKGFLEEIGEG---KGKGYNLNIPLPKG-LNDNEFLFALEKSLEIVKEVFEPEVYLLQLGTDPLLEDYLSKFNLSNVAFLKAFNIVREVFGEGVYLGGGGYHPYALARAWTLIWCELSGREVPE------------------------------------

General information: TITO was launched using: RESULT: Template: 1C3R.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1920 -30347 -15.81 -96.96 target 2D structure prediction score : 0.73 Monomeric hydrophicity matching model chain A : 0.64 3D Compatibility (PKB) : -15.81 2D Compatibility (Sec. Struct. Predict.) : 0.73 1D Compatibility (Hydrophobicity) : 0.64 QMean score : 0.416

(partial model without unconserved sides chains): PDB file : Tito_1C3R.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1C3R-query.scw PDB file : Tito_Scwrl_1C3R.pdb: