Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MERYTVMGQLGDGSFGTVSKAQNTSTGEIVAVKKMKQRFHSWEECL---QLREIQSLRKVQHPNLVKLKEVVREKTELFMIFEYCEKNIFQIQRQRANEMSGTMAFSDKEIRSIMCQTLLGVQAIHKAGFMHRDLKPENLLISGD-LVKVADFGLAKE----IRSRPPFTEYVSTRWYRAPELVLHSTHYNSPVDIWACAVIFAELYLCRPLFPGTSESDQLFKICSVLGSPAPNEWDEGYQLARRMNMRFPTVAPTPLRHILTTAPPAAVDLMAQMLRFNPAERPTATQCLQHPYFTGSGGSSALYAGIATGQPHNPFQLAASSAVAAQSMSNVGLTSNSSPPPTTSNASLFKYANLFNQGNRSPLSVSSTSAPFSGSSALQGSVTSSNMVRSVPTQRKTSVPNAVDSDDEFNF 5HQ0 Chain:A ((6-292)) MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI--RLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDL----KKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV---YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT-FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF----------------------------------------------------------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 5HQ0.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1336 5825 4.36 20.88 target 2D structure prediction score : 0.57 Monomeric hydrophicity matching model chain A : 0.72 3D Compatibility (PKB) : 4.36 2D Compatibility (Sec. Struct. Predict.) : 0.57 1D Compatibility (Hydrophobicity) : 0.72 QMean score : 0.471

(partial model without unconserved sides chains): PDB file : Tito_5HQ0.pdb: (Unconserved sides chains are recalculated) : Sequence: align-5HQ0-query.scw PDB file : Tito_Scwrl_5HQ0.pdb: