Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSTGDLLTPGALWQDDANVFVCSGRRCGRRFNRLFCPKHHCRWCGRVYCDACAPKQTIYKRQLLRKCNRCRLPAVFRHSWNARTRGMDCTPFECIISYLTPRSITALLQSCHTMMSEFPVCGYPFYDSIQQRFPSFYPGAQIGRGTFGTVFKCEDRSAADHKRAILKCISKATNLTYTRWMGALTELRILESVNHPNVAHLLGAFQTREDLVIVMEAGEGGTARRAAACVREYGQAAEEAFTANIIEGVASGLDYLYREKHIIHRDIKLDNIVL--SADYSTPMII-DFGLAEFVVNEEEQWYVVGGTRNYAAPESIAAVANGHVDMREPGITMHKGDLFSLGVVAYYLLSGHRPFRSRSFDK--MHEEMRRG-VACTGPLWDGVSSDARELVQALLSYDPAQRPDYAAIKENPFIMARAAGVKSIQMQRNARLLLDEEETHAEWVTLEPSDLREAVDEGESEVLLPLSTPQRWYHAYLPRFSLLHL 5JZJ Chain:A ((27-295)) -------------------------------------------------------------------------------------------------------------------------GFQIPATITERYKV---GRTIGDGNFAVVKECVERSTA--REYALKIIKKSKCRGKEHMIQ--NEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNL----ASAIKYLHS-LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV---DGPLYTVCGTPTYVAPEIIAETGYG-----------LKVDIWAAGVITYILLCGFPPFRGS----EVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWV-----------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 5JZJ.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1290 -111633 -86.54 -431.02 target 2D structure prediction score : 0.64 Monomeric hydrophicity matching model chain A : 0.66 3D Compatibility (PKB) : -86.54 2D Compatibility (Sec. Struct. Predict.) : 0.64 1D Compatibility (Hydrophobicity) : 0.66 QMean score : 0.394

(partial model without unconserved sides chains): PDB file : Tito_5JZJ.pdb: (Unconserved sides chains are recalculated) : Sequence: align-5JZJ-query.scw PDB file : Tito_Scwrl_5JZJ.pdb: