Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEQIEWNDFLKVELRVGKIIQAEVFEKARKPAYILHVDFGEELGVRKSSAQITKLYQPQDLIGKLVVAVVNFPKKQIGPIQSECLVTGFHNADGDVALCIPEFEVPLGTKLL 2Q2I Chain:A ((7-115)) --EISYADFEKVDIRVGTIVEAVPFPEARKPAIKVKIDFGPEIGIKKSSAQITVHYTPESLVGRQVLGVVNFPPRQIGPFRSEVLTLGFADANGDIVLAAVERPVPNGEKM-

General information: TITO was launched using: RESULT: Template: 2Q2I.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 488 -51065 -104.64 -468.49 target 2D structure prediction score : 0.46 Monomeric hydrophicity matching model chain A : 0.83 3D Compatibility (PKB) : -104.64 2D Compatibility (Sec. Struct. Predict.) : 0.46 1D Compatibility (Hydrophobicity) : 0.83 QMean score : 0.555

(partial model without unconserved sides chains): PDB file : Tito_2Q2I.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2Q2I-query.scw PDB file : Tito_Scwrl_2Q2I.pdb: