Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MMRIGLFLLTNLAVLVVAGIILSLFGVGSYHGAGGLNLGNLLVICFVFGMVGSLVSLFMSKWMAKKTTGTELIDPNAPRNQAESWLLQTVAELSQRAGINMPEVGIFP----SYQSNAFATGWNKNDALVAVSSGLLERMNKDELRAVLAHEIGHVANGDMVTLALIQGVVNAFVMF--FARVVGDFIDRNVFGRQDNEAPGMGYFIITMVLDIVFGIL------------ASAIVMWFSRYREYRADEAGARLAGKQAMISALLRLQAETELPDQMPKEMKAFAIAEGKEQGFSLAALFQTHPTIEQRVAALHQLDCP 4IL3 Chain:A ((232-444)) -------------------------------------------------------------------------------------LKKSIESLADRVGFPLDKIFVIDGSKRSSHSNAYFTGLPFTSKRIVLFDTLVNSNSTDEITAVLAHEIGHWQKNHIVNMVIFSQ-LHTFLIFSLFTSIYRNSSFYNTF-------SGFVDPVITKEFPIIIGFMLFNDLLTPLECAMQFIMSLISRTHEYQADAYAKKLGYKQNLCRALIDLQI---------KNLSTMNVDPL------YSSYHYSHPTLAERLTAL------

General information: TITO was launched using: RESULT: Template: 4IL3.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 568 -57379 -101.02 -306.84 target 2D structure prediction score : 0.55 Monomeric hydrophicity matching model chain A : 0.65 3D Compatibility (PKB) : -101.02 2D Compatibility (Sec. Struct. Predict.) : 0.55 1D Compatibility (Hydrophobicity) : 0.65 QMean score : 0.277

(partial model without unconserved sides chains): PDB file : Tito_4IL3.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4IL3-query.scw PDB file : Tito_Scwrl_4IL3.pdb: