Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKKPVPKIYRTTNWSSYNQALIKRGNISIWFDPKTQWYAQPQGKHGRNQTYSDAAIQCCLMIKSLFRLSLRMVTGFAQSLIKLCGLNWTAPDYSTLCRRQKRIDIAISYQQSRDGLHLLVDSTGLKFLGEGEWKRKKHQPAYRRQWRKLHIGIDAKTLQIRAVQLTTNNVSDSQVLGDLLDQIPLDERIDSVYTDGAYDTKHCRQVILDRDAHAVIPPRKNAKPWKDKKLRSLARNELLKTVKRLGRSLWKKWSGYHRRSLVETKMHCIK 4A3C Chain:A ((915-988)) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGSEILGDLKLQVLLDEE----YKQLVKDRKFLREVFVDGEANWPLP-----------------------------------------------------

General information: TITO was launched using: RESULT: Template: 4A3C.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 20 -1631 -81.53 -37.92 target 2D structure prediction score : 0.56 Monomeric hydrophicity matching model chain A : 0.58 3D Compatibility (PKB) : -81.53 2D Compatibility (Sec. Struct. Predict.) : 0.56 1D Compatibility (Hydrophobicity) : 0.58 QMean score : 0.312

(partial model without unconserved sides chains): PDB file : Tito_4A3C.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4A3C-query.scw PDB file : Tito_Scwrl_4A3C.pdb: