Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTKKQIQIFFERLREQRPSPQTELKYSSPFELLIAVMLSAQATDVSVNKATDKLYPVANTAEKIYNLGVDGLKEYIKTIGLYNAKAENVIKTCKILMEQFNGEVPSNRKDLEALPGVGRKTANVVLNTAFGQPTMAVDTHIFRVGNRTGLA-IGKNVLEVEHRLVKVIPKEFILDAHHWLILHGRYCCIARKPKCSECVVADVCNWPDRFEFGAQKQIAVKNIEAE 1P59 Chain:A ((5-208)) LTKQQIRYCLDEMAKMFPDAHCELVHRNPFELLIAVVLSAQCTDALVNKVTKRLFEKYRTPHDYIAVPLEELEQDIRSIGLYRNKARNIQKLCAMLIDKYNGEVPRDRDELMKLPGVGRKTANVVVSTAFGVPAIAVDTHVERVSKRLGFCRWDDSVLEVEKTLMKIIPKEEWSITHHRMIFFGRYHCKAQSPQCPSCPLLHLC----------------------

General information: TITO was launched using: RESULT: Template: 1P59.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 942 -124909 -132.60 -615.32 target 2D structure prediction score : 0.61 Monomeric hydrophicity matching model chain A : 0.83 3D Compatibility (PKB) : -132.60 2D Compatibility (Sec. Struct. Predict.) : 0.61 1D Compatibility (Hydrophobicity) : 0.83 QMean score : 0.475

(partial model without unconserved sides chains): PDB file : Tito_1P59.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1P59-query.scw PDB file : Tito_Scwrl_1P59.pdb: