Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY 4U17 Chain:C ((6-88)) WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY

General information: TITO was launched using: RESULT: Template: 4U17.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain C - contact count / total energy / energy per contact / energy per residue : 243 -9170 -37.74 -110.48 target 2D structure prediction score : 0.71 Monomeric hydrophicity matching model chain C : 1.00 3D Compatibility (PKB) : -37.74 2D Compatibility (Sec. Struct. Predict.) : 0.71 1D Compatibility (Hydrophobicity) : 1.00 QMean score : 0.500

(partial model without unconserved sides chains): PDB file : Tito_4U17.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4U17-query.scw PDB file : Tito_Scwrl_4U17.pdb: