Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence -------TVASRRDDCWVS--------LFQYKANGEREAIYVDYSPPNSLVIFVHDGWRLNVQLDQHCRSLFPNDIRKQLVEGFGVHSYSKMNEVAGQKPLARSQ 1KP6 Chain:A ((1-79)) NNAFCAGFGLSCKWECWCTAHGTGNELRYATAAGCGDHLSKSYYDARAGHCLFSDD---LRNQFYSHCSSLNNNMSCRSLSK-----------------------

General information: TITO was launched using: RESULT: Template: 1KP6.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 252 5411 21.47 84.54 target 2D structure prediction score : 0.48 Monomeric hydrophicity matching model chain A : 0.62 3D Compatibility (PKB) : 21.47 2D Compatibility (Sec. Struct. Predict.) : 0.48 1D Compatibility (Hydrophobicity) : 0.62 QMean score : 0.250

(partial model without unconserved sides chains): PDB file : Tito_1KP6.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1KP6-query.scw PDB file : Tito_Scwrl_1KP6.pdb: