Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKTYDAIIIGSGVSGLSAAYGLKEAGKTVLVVEEDLWGGTCPNRGCDPKKVLLSAVEARNRVKQ-LSGKGFNEI-PTANWEELQKFKRTFTDPVPESRKKQLAE-AEIDHLSGTARFLDDSSIEVNEEVFHADYLVLATGQRPTILPVEGKEYLKTSADFLSLPVLPKEIIFIGGGYIAFELATIANAAGSKVTIVHHNQRPLKEFEASLVEEAVHQMEASGIQFAFGVETQKIIS-EGTRYRLV-GKETELVADMIFCATGRQPNTESLALEQANIVF-DKHGIAVNDYLQTSNPKIFACGDIVSRKTPKLTPVATFEGNYVAKRITDAT-SEPIKYPIIPTIVYASPKLAEVGVTKSHASSS-D----QVVEMDL---TSWFTYHRVNEPVAKAELTFDQ-QNYLIGAAVISEQADELIDDLTLVINQKLTKKELDSYIMGYPTLASDLSYLLK 1GES Chain:B ((2-447)) TKHYDYIAIGGGSGGIASINRAAMYGQKCALIEAKELGGTCVNVGCVPKKVMWHAAQIREAIHMYGPDYGFDTTINKFNWETLIASRTAYIDRIHT-SYENVLGKNNVDVIKGFARFVDAKTLEVNGETITADHILIATGGRPSHPDIPGVEYGIDSDGFFALPALPERVAVVGAGYIGVELGGVINGLGAKTHLFEMFDAPLPSFDPMISETLVEVMNAEGPQLHTNAIPKAVVKNTDGSLTLELEDGRSETVDCLIWAIGREPANDNINLEAAGVKTNEKGYIVVDKYQNTNIEGIYAVGDNT--GAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTVGLTEPQAREQYGDDQVKVYKSSFTAMYTAVTTH---RQPCRMKLVCVGSEEKIVGIHGIGFGMDEMLQGFAVALKMGATKKDFDNTVAIHPTAAEEFV----

General information: TITO was launched using: RESULT: Template: 1GES.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain B - contact count / total energy / energy per contact / energy per residue : 2439 33495 13.73 77.89 target 2D structure prediction score : 0.57 Monomeric hydrophicity matching model chain B : 0.74 3D Compatibility (PKB) : 13.73 2D Compatibility (Sec. Struct. Predict.) : 0.57 1D Compatibility (Hydrophobicity) : 0.74 QMean score : 0.504

(partial model without unconserved sides chains): PDB file : Tito_1GES.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1GES-query.scw PDB file : Tito_Scwrl_1GES.pdb: