Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTEGVGLPLWLLAELTYRCLLQCPYCSNPLDYAQHKNELTTQEWFDVFDQARQMGAVQLGFSGGEPLVRQD---LEQLVAHAHQLGF----YTNLVTSGMGLTEQRISHLKQAGLDHIQISFQASDPVLNDALAGS--KHAFEQKYEMCRLVKKYDYP-MVLNF--VIHRH---NIDQIDKIIELCLEL--NADTVELAICQFYGWAFLNRQGLLPTQEQLIRAERITNEYREKLKAQNHPCKLIFVVPDYYEERPKACMNGWGKIFFTVAPDGMALPCHAARQLP-ISFPNVREQSLSRIWYESTGFNRFRGDAWMPEGCRSCPDKDRDFGGCRCQAYMLTGDASNADPVCGKSPYHQFIEQARAESEIDSSLEKLVFRNSRNSKQFTVQQNIPVQNIVDD 4WCX Chain:A ((91-422)) -----RIVIFAPLYVSNYCVNNCRYCGYRHSNEQQRKKLTMEEVRREVEILEEMGHKRLAVEAGEDPVNCPIDYIVDVIKTIYDTKLKNGSIRRVNVNIAATTVENYKKLKKVGIGTYVLFQETYHRPTYEYMHPQGPKHDYDYHLTAMDRAMEAGIDDVGLGVLYGLYDYKYETVAMLYHANHLEEKFGVGPHTISVPRLRPALNISIDKFPYIVSDKDFKKLVAVIRMA---V-PY---TGMILSTREKPKFREEVISI--GISQISAGSCTGVGGYHEE--KPQFEVEDKR--SPNEILRT------LCEQGYLPSYCTAC-Y-RMGRTGDRFMSFAKSGQI---HNFCLP------------------------------------------------

General information: TITO was launched using: RESULT: Template: 4WCX.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1712 -37113 -21.68 -120.89 target 2D structure prediction score : 0.61 Monomeric hydrophicity matching model chain A : 0.66 3D Compatibility (PKB) : -21.68 2D Compatibility (Sec. Struct. Predict.) : 0.61 1D Compatibility (Hydrophobicity) : 0.66 QMean score : 0.322

(partial model without unconserved sides chains): PDB file : Tito_4WCX.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4WCX-query.scw PDB file : Tito_Scwrl_4WCX.pdb: