Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MENQNKLYHFVGIKGSGMSSLALVLHEQGLNVQGSDIEKYFFTQRDLEKANITIL-PFNADNVKPGMTIIAGNAFPDSHEEIQRAKELGLEVIRYHDFIGHFIQNYTSIAVTGSHGKTSTTGLLSHVLS--GVRPTSYLIGDGTG-H--G---DPQAEFFSFEACEYRRHFLAYSPDYAIMTNIDFDHPDYYT-SIDDVFTAFQTMAGQVK--KAIFAYGDDAYLRKLKANV--PIYYYGVTE-NDDIQARNIERTTSGSAFDVYHGDEFVGHFTVPAFGKHNILNALGVIAVAY-FEKLDLKEVAEEMLTFPGVKRRFSEKI-----VADMTVVDDYAHHPAEIKATIDGARQKYPDKEIIAVFQPHTFTRTIALMDEFAEALDLADKVYLCDIFGSAREEQG-NVKIEDLGAKIKKGG----EVI-KENNVSPLL---DYHDAVVIFMGAGDVQKFEQAYEKLLSSTTKNVL 1P3D Chain:A ((14-473)) EMRRVQQIHFIGIGGAGMSGIAEILLNEGYQISGSDIAD-GVVTQRLAQAGAKIYIGHAEEHIEGASVVVVSSAIKDDNPELVTSKQKRIPVIQRAQMLAEIMRFRHGIAVAGTHGKTTTTAMISMIYTQAKLDP-TFVNGGLVKSAGKNAHLGA-SRYLIAEADESDASFLHLQPMVSVVTNMEPDHMDTYEGDFEKMKATYVKFLHNLPFYGLAVMCADDPVLMELVPKVGRQVITYGFSEQADY-RIEDYEQTGFQGHYTVICPNNERINVLLNVPGKHNALNATAALAVAKEEG-IANEAILEALADFQGAGRRFDQLGEFIRPNGKVRLVDDYGHHPTEVGVTIKAAREGWGDKRIVMIFQPHRYSRTRDLFDDFVQVLSQVDALIMLDVYA-AGEAPIVGADSKSLCRSIRNLGKVDPILVSDTSQLGDVLDQIIQDGDLILAQGAGSVSKISRGLAESW--------

General information: TITO was launched using: RESULT: Template: 1P3D.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2564 -17354 -6.77 -40.36 target 2D structure prediction score : 0.68 Monomeric hydrophicity matching model chain A : 0.76 3D Compatibility (PKB) : -6.77 2D Compatibility (Sec. Struct. Predict.) : 0.68 1D Compatibility (Hydrophobicity) : 0.76 QMean score : 0.500

(partial model without unconserved sides chains): PDB file : Tito_1P3D.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1P3D-query.scw PDB file : Tito_Scwrl_1P3D.pdb: