Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence WFHGKLSRREAEALLQ-----LNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE-GVRW----GFAMLPKLFLNS 2HDV Chain:A ((527-610)) WFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKHLRLSLNAAGQCRVQHLHFQSIFDMLEH-

General information: TITO was launched using: RESULT: Template: 2HDV.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 228 4409 19.34 65.80 target 2D structure prediction score : 0.64 Monomeric hydrophicity matching model chain A : 0.69 3D Compatibility (PKB) : 19.34 2D Compatibility (Sec. Struct. Predict.) : 0.64 1D Compatibility (Hydrophobicity) : 0.69 QMean score : 0.619

(partial model without unconserved sides chains): PDB file : Tito_2HDV.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2HDV-query.scw PDB file : Tito_Scwrl_2HDV.pdb: