Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence ------------------MVIK-----KKRE-KEMFENKKIKINVSDFQKVSAVTAVMMQTILSFALANSHSATNTAFLGTFYVIVKYTAPMF-----------IFAIVYNMVKTSQHLSYWEFLKEKFFELVVPYLLWTTAYL-WLFPAVQQQTPYTDTASFLLK-YVTG-DGAPHLWYTVMMLQIQLFMPFFVWL-GYKVFANKKYVWPVLIGSTILYVAWYLFYQTQVLTGP-YHDSWYLLDRFVASFMIYGVAAFVYHEKVYQYLDRVRYLFLPVALVIA-----------------------------FFSVRSLLAHPGDLSFA-----NAPYLNTIQSLYSLV----------------IIFAVFIGASKMIVNDSPK----------------LP-LFKWLSVYAYRTYLAN-V-----------FVFQVLLLLFKDS-WLQLPSGVMILVAYLMTASCA--FALSWLLHIIWVAIKKGFSK-------------------------- 4C0E Chain:A ((1674-2193)) LEAAHLLEQMEYVFDEWIHLCNNPHATERAAMIFVHQLHSVQLVTNRDEFLLFLRHALDKSVERFEQGIHSGASIAESFQAVEALVKLIIIFVKSHSAAVAFMDSILALGVLVANSHHVKRGENFNQRVFYRFFALLLHEVGLLAGHFSKSHYEQIILNFAARLFDMRPNLLPGFACAWAGLV--SHRAFLPVILGLPDEKGWAPFTKLLEQFLGCVGELVK---TFTVSSLGKEMYHAALKILIVLQHDFPIYLDK---FRVQLCQSLPLHATQLVNLILAAIPPNCNSLADPFQAGLKVDKIPDMKERPPTAFDSAGLLREAGLLDILERMLQNGPSEDGVAQINHAINKSTSFGYVPLGVNRRLIDAVVARFAEFAINRASSRSDSAIFVAGANDIKTLQMLVTEVSPEARYYLVSSMVNELRYPNAYTNYFSQALLDIFGHDMSDPEENLVREQIVRVLLERVLGYWPQPWGLIITILELLKNDKYLFFELPFIKATPEVAERFTALARSAA

General information: TITO was launched using: RESULT: Template: 4C0E.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 21 -922 -43.90 -2.56 target 2D structure prediction score : 0.57 Monomeric hydrophicity matching model chain A : 0.61 3D Compatibility (PKB) : -43.90 2D Compatibility (Sec. Struct. Predict.) : 0.57 1D Compatibility (Hydrophobicity) : 0.61 QMean score : ?

(partial model without unconserved sides chains): PDB file : Tito_4C0E.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4C0E-query.scw PDB file : Tito_Scwrl_4C0E.pdb: