Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTSSYRQQLQAKIDRITTQFSEFTPPTLEVFESPEQHFRMRAEFRIWHTENDMFYAMFERNDDGKQKTVVRIDEFPIADKSINDLMPLLLAELKANSLLSQRLFEVDFLATLSGEMLVTLIYHRKLNQEWEQAAKALAEKLNIKIMGRSRGQKIVIGDDFVVEEFELLNRSFKYKQIESSFTQPNAQVCKKMLQWACDAAEGSKKHLLELYCGNGNFTLPLSLKF-ERVLATELAKSSVYAAQWNIEQNQIDNIQVARLSAEEFTQAYQGEREFRRLQEADIDIQSYDFGTVFVDPPRAGIDDE-TLKLLQ---GFERIIYISCNPDTLY-ENLKTLT--QTHRVTK------FALFDQFPYTHHVESGVLLEKI 1WY7 Chain:C ((50-195)) -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKVVADLGAGTGVLSYGALLLGAKEVICVEVDKEAVDVLIENLGEFK-GKFKVFIGDVSEF----N-----------------SRVDIVIMNPPFGSQRKHADRPFLLKAFEISDVVYSIHLAKPEVRRFIEKFSWEHGFVVTHRLTTKIEIP------RKKLERITV----

General information: TITO was launched using: RESULT: Template: 1WY7.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain C - contact count / total energy / energy per contact / energy per residue : 565 -6416 -11.36 -50.92 target 2D structure prediction score : 0.37 Monomeric hydrophicity matching model chain C : 0.59 3D Compatibility (PKB) : -11.36 2D Compatibility (Sec. Struct. Predict.) : 0.37 1D Compatibility (Hydrophobicity) : 0.59 QMean score : 0.425

(partial model without unconserved sides chains): PDB file : Tito_1WY7.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1WY7-query.scw PDB file : Tito_Scwrl_1WY7.pdb: