Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEQFQGSAKMKKNAKQIVHELYNDISIS-KDPKYSDILEVLQKVYLKLEKQKYELDPSPLINRLVNYLYFTAYTNKIRFTEYQEELIRNLSEIGRTAGINGLYRADYGDKSQF 2IP6 Chain:A ((7-93)) -------EHIKQQALDLFTRLQFLLQKHDTIEPYQYVLDILETGISKTKHNQQ--TPERQARVVYNKIASQALVDKLHFTAEENKVLAAINELAHS-----------------

General information: TITO was launched using: RESULT: Template: 2IP6.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 309 -5273 -17.06 -61.31 target 2D structure prediction score : 0.80 Monomeric hydrophicity matching model chain A : 0.68 3D Compatibility (PKB) : -17.06 2D Compatibility (Sec. Struct. Predict.) : 0.80 1D Compatibility (Hydrophobicity) : 0.68 QMean score : 0.644

(partial model without unconserved sides chains): PDB file : Tito_2IP6.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2IP6-query.scw PDB file : Tito_Scwrl_2IP6.pdb: