Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence WYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYY 5DC4 Chain:A ((18-93)) WYHGPVSRNAAEYLLSS--GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHH

General information: TITO was launched using: RESULT: Template: 5DC4.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 275 -47608 -173.12 -626.42 target 2D structure prediction score : 0.84 Monomeric hydrophicity matching model chain A : 0.77 3D Compatibility (PKB) : -173.12 2D Compatibility (Sec. Struct. Predict.) : 0.84 1D Compatibility (Hydrophobicity) : 0.77 QMean score : 0.625

(partial model without unconserved sides chains): PDB file : Tito_5DC4.pdb: (Unconserved sides chains are recalculated) : Sequence: align-5DC4-query.scw PDB file : Tito_Scwrl_5DC4.pdb: