Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MNLWDIFFTTQATEPPKFDLFWYV-SLFTLLALTFYTAHRYRENKVYQRFFQILQTVQLILLYGWYWVNHMPLSESLPFYHCRMAMFVVLLLPGQSKYKQYFALLGTFGTLAAFVYPVPDAYPFPHITILSFIFGHLALLGNSLVYLLRQYNARLLDVKGIFLMTFALNALIFVVNLVTGGDYGFLTKPPLVGDHGLVANYLLVSIVLVATISLTKKILEFFLAQEAEKMIAKEA 1IC8 Chain:A ((3-192)) KELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHARNRFKWG-------PASQQILFQAYERQKNPS--------------KEERETLVEECNRAECIQRG----------------------------VSPSQAQGLGSNLV------------TEVRVYNWFANRRKE----EA

General information: TITO was launched using: RESULT: Template: 1IC8.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 579 -9919 -17.13 -58.69 target 2D structure prediction score : 0.49 Monomeric hydrophicity matching model chain A : 0.51 3D Compatibility (PKB) : -17.13 2D Compatibility (Sec. Struct. Predict.) : 0.49 1D Compatibility (Hydrophobicity) : 0.51 QMean score : 0.308

(partial model without unconserved sides chains): PDB file : Tito_1IC8.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1IC8-query.scw PDB file : Tito_Scwrl_1IC8.pdb: