Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKTETTIQGLAASLNPARAARKIIGFVPTMGNLHEGHLTLVREAKKLCDVVVVSIFVNPTQFGPGEDFDNYPRTLEQDSRLLADVGCDIIFAPSVEQMYGTQPRLTNISVSQITDDLCGSSRPGHFDGVALVVTKLFNIVQPNYAFFGQKDYQQLAVIRQFVQDLNIPLEVIGVPIVRAEDGLALSSRNGYLTPEQRQVAPVIYQGLKQAEEQLHQGKDLQQVL-ADLKTLLTDNGFVVDYVEA-RQPNLLA--ASQFDRDIVLFVAAKLGGTRLIDNLQVAFTPQ 3INN Chain:C ((22-298)) MQIIHTIEELRQALAPARQQGKKIGFVPTMGYLHKGHLELVRRARVENDVTLVSIFVNPLQFGANEDLGRYPRDLERDAGLLHDAQVDYLFAPTVSDMY-PRPMQTVVDVPPLGNQIEGEARPGHFAGVATVVSKLFNIVGPDAAYFGEKDFQQLVIIRRMVDDMAIPVRIVGVETVREDDGLACSSRNVYLTPEQRRAAIIVPQALDEADRLYRSGMDDPDALEAAIRTFIGRQPLAVPEVIAIRDPETLERLPALQGRPILVALFVRVGATRLLDN--------

General information: TITO was launched using: RESULT: Template: 3INN.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain C - contact count / total energy / energy per contact / energy per residue : 1354 -143022 -105.63 -523.89 target 2D structure prediction score : 0.66 Monomeric hydrophicity matching model chain C : 0.83 3D Compatibility (PKB) : -105.63 2D Compatibility (Sec. Struct. Predict.) : 0.66 1D Compatibility (Hydrophobicity) : 0.83 QMean score : 0.569

(partial model without unconserved sides chains): PDB file : Tito_3INN.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3INN-query.scw PDB file : Tito_Scwrl_3INN.pdb: