Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MAIRRIEGLLHLASEGRYAILVGRFNSFVVEHLLEGAIDTLKRHGVNEDNITVIHAPGAWELPIVAKKLATSNQFDAIIALGAVIRGSTPHFDFVAGECAKGLGVVALESSLPVINGVLTTDSIEQAIERSGT--KAGNKGSEAALTAIEMVNLLKAI 2C92 Chain:E ((15-156)) ------------ASGVRLAIVASSWHGKICDALLDGARKVAAGCGLD--DPTVVRVLGAIEIPVVAQELA--RNHDAVVALGVVIRGQTPHFDYVCDAVTQGLTRVSLDSSTPIANGVLTTNTEEQALDRAGLPTSAEDKGAQATVAALATALTLREL

General information: TITO was launched using: RESULT: Template: 2C92.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain E - contact count / total energy / energy per contact / energy per residue : 765 -115903 -151.51 -827.88 target 2D structure prediction score : 0.64 Monomeric hydrophicity matching model chain E : 0.81 3D Compatibility (PKB) : -151.51 2D Compatibility (Sec. Struct. Predict.) : 0.64 1D Compatibility (Hydrophobicity) : 0.81 QMean score : 0.593

(partial model without unconserved sides chains): PDB file : Tito_2C92.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2C92-query.scw PDB file : Tito_Scwrl_2C92.pdb: