Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MCGIVGGVAERCVTEILIEGLKRLEYRGYDSAGVALLNNQ-QILRERRVGKVANLADAVSEHQLTGAIGIAHTRWATHGKPTENNAHPHMSGKVAVVHNGIIENYQELKDDLQALGYVFTSQTDTEVVAHLVAEALKNTDSLLEAVESVVPQLKGAYALGIIHSDYPDELITVREGSPLVIGVGIGENFISSDQLALLPVTNRFIYLEEGDIARLTRTSIEVFVK-GERVERPVKELDATVSSASKGEYKHYMLKEIYEQPEAIKQTISQALD-GNNLRDDFLKDADADFSKLQSVQIIACGTSYHSGMIAKYWFEQLIGVPCQVEIASEFRYRSPVIVENTLYICISQSGETADTLAALRETQKRAKANNIDIQTLTICNVATSSMVRETDHHLLTLAGPEIGVASTKAFTTQLAALMLLILKIGQVKQRISNVMIEELARELWHSPKVILDTLKNDPEILRLSELFVEKQHCLFLGRGTHYPIALEGALKLKEISYIHAEGYAAGELKHGPLALVDNEMPIVILAPNDEMLDKLKSNMEEVQARGGELFVFADENSGVVEKDRQHVVHTPAVNEWLAPIIYSVPVQLLSYHVAVLRGTDVDQPRNLAKSVTVE 2J6H Chain:A ((1-608)) -CGIVGAIAQRDVAEILLEGLRRLEYRGYDSAGLAVVDAEGHMTRLRRLGKVQMLAQAAEEHPLHGGTGIAHTRWATHGEPSEVNAHPHVSEHIVVVHNGIIENHEPLREELKARGYTFVSETDTEVIAHLVNWELKQGGTLREAVLRAIPQLRGAYGTVIMDSRHPDTLLAARSGSPLVIGLGMGENFIASDQLALLPVTRRFIFLEEGDIAEITRRSVNIFDKTGAEVKRQDIESNLQYDAGDKGIYRHYMQKEIYEQPNAIKNTLTGRISHGQVDLSELGPNADELLSKVEHIQILACGTSYNSGMVSRYWFESLAGIPCDVEIASEFRYRKSAVRRNSLMITLSQSGETADTLAGLRLSKELGY-----LGSLAICNVPGSSLVRESDLALMTNAGTEIGVASTKAFTTQLTVLLMLVAKLSRLKGLDASIE-HDIVHGLQALPSRIEQMLSQDKRIEALAEDFSDKHHALFLGRGDQYPIALEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGQLYVFADQDAGFVSSDNMHIIEMPHVEEVIAPIFYTVPLQLLAYHVALIKGTDVDQPRNLAKSVTVE

General information: TITO was launched using: RESULT: Template: 2J6H.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 3895 -61055 -15.68 -100.92 target 2D structure prediction score : 0.63 Monomeric hydrophicity matching model chain A : 0.89 3D Compatibility (PKB) : -15.68 2D Compatibility (Sec. Struct. Predict.) : 0.63 1D Compatibility (Hydrophobicity) : 0.89 QMean score : 0.554

(partial model without unconserved sides chains): PDB file : Tito_2J6H.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2J6H-query.scw PDB file : Tito_Scwrl_2J6H.pdb: