Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSIEKFSVEKVLSVHRWTPTLFSFTMTRPSHFKFTAGQFARIGLKVGDELIVRAYSVVSSPFDETLEFFSIVVPDGAFTSNLQHLKVGDELYLEKIPYGYLTLARYQQPLP-HDLWLLATGTGLAPFLSMLQDFETWSNYQKINLVYSVRTAAELAYVDRIQEI---AETFGEGHLGFKFI--PIITRDPSAPLHERLPVLIENGELEKVAGL-ELSPASSHVMLCGNPQMVDDTKEALKRCGLTMN-RRGE-GNIAVENYW 2QDX Chain:A ((5-252)) -------TERVLSVHHWNDTLFSFKTTRNPGLRFKTGQFVMIGLEVDGRPLMRAYSIASPNYEEHLEFFSIKVPDGPLTSRLQHLKEGDELMVSRKPTGTLV---HDDLLPGKHLYLLSTGTGMAPFLSVIQDPETYERYEKVILVHGVRWVSELAYADFITKVLPEHEYFGD-QVKEKLIYYPLVTREPFRN-QGRQTDLMRSGKLFEDIGLPPMNPQDDRAMICGSPSMLEETSAVLDSFGLKISPRMGEPGDYLIER--

General information: TITO was launched using: RESULT: Template: 2QDX.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1251 -66402 -53.08 -277.83 target 2D structure prediction score : 0.44 Monomeric hydrophicity matching model chain A : 0.79 3D Compatibility (PKB) : -53.08 2D Compatibility (Sec. Struct. Predict.) : 0.44 1D Compatibility (Hydrophobicity) : 0.79 QMean score : 0.557

(partial model without unconserved sides chains): PDB file : Tito_2QDX.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2QDX-query.scw PDB file : Tito_Scwrl_2QDX.pdb: