Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKMKLLMTSVLSTSLFLVACGGGSSDDGPATTNPSGTPTNNIQNPVVKVEAYTSTNLGSVAAESSILTYKMLGQSGQEVQATSLVFTPNTPPPVGGWPIVVWAHGTTGVADACAPSKAALADSTKDLISKLLAAGYVVVAPDYEGLGTPGIHPFLNVKSE---------------AFSITDAVVAARNYLSQRNLLTSKKWGTVGHSQGGHAALGAAQYANRAQLDYKGTVAVAPASNWGSILVDGEAQVANAPIDIKIGTYAQLDTYTALVTAGIRNTQPSFDYGQVFTSQISSIAAQAENLCSGPLYGAFYEGMSNYAKDHNGTLDGFTRTQPNFMAVPLVKTFLEKDSQPLQVKVTTPIIIYQGIADPTVPKLATDLLISNATVVGTKINSYVTGNWDHGTAMSSNVDNIVGNVQTLLSAQ 1L7A Chain:A ((1-318)) MQLFDLPLDQLQTY--------KPEKTAPKDFSEFWKLSLEELAKVQAEPDLQPVDYPADGVKVYRLTYKSFG----NARITGWYAVPDKEGP---HPAIVKYHGYNASYDGEIHEMVNWALH-----------GYATFGMLVRGQQRSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRALEVISSFDEVDETRIGVTGGSQGGGLTIAAAAL------------------------------------------------------------SDIPKAAVADYPYLSNFERAIDVALEQP-----YLEINSFFRRNG----------SPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTP-PSTVFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQILKG----

General information: TITO was launched using: RESULT: Template: 1L7A.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1865 -30878 -16.56 -101.91 target 2D structure prediction score : 0.63 Monomeric hydrophicity matching model chain A : 0.59 3D Compatibility (PKB) : -16.56 2D Compatibility (Sec. Struct. Predict.) : 0.63 1D Compatibility (Hydrophobicity) : 0.59 QMean score : 0.239

(partial model without unconserved sides chains): PDB file : Tito_1L7A.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1L7A-query.scw PDB file : Tito_Scwrl_1L7A.pdb: