Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSKLIVLSNRISMPSGKASAGGLAVAVQDALNDSNGIWLGWNGQQITDTEAPEFDQAYSHGIDYITCPLTHQQYAQYYCGFANKVLWPAMHDRDDLIEYNAEEYNTYQKVNRLFAEKLQQIAQPDDLIWVHDYHFFSVARHCRELGMQNKIGFFLHIPFASLNIWRKIPVALQLVQDLCQYDVIGLQTQTDQNTCMQTCMGLLEAQKILSDRISYKKRQILIKSYPIGVQPELIQRQAQQAFHTPYVFNFEDIPRQKTIIGVDRIDYSKGLLERFNAFATFLETNPEYHGLVRHLQVATPSRTDIPAYQRLYQRFKAKLELINEEFAHEDWRPIDCCFDTVQHDSLMHIYRRSDICWISSLRDGMNLVAKEYIAAQDPENPGVLILSKYAGAAEQMTQALIVDPLDRAAMMDSLKTALEMSKAERINRYEQLIEGLAATDLSDWRNNFLKDLENSPTFTKSKLSLQEKYQPTYHAL 2WTX Chain:C ((2-452)) -SRLVVVSNRIAP--------GLAVGILGALKAAGGLWFGWSGE--TGN--QPLKKVKKGNITWASFNLSEQDLDEYYNQFSNAVLWPAFHYRLDLVQFQRPAWDGYLRVNALLADKLLPLLQDDDIIWIHDYHLLPFAHELRKRGVNNRIGFFLHIPFPTPEIFNALPTYDTLLEQLCDYDLLGFQTENDRLAFLDCLSNLTRVTTRSAKSHTAWGKAFRTEVYPIGIEPKEIAKQAAGP-----AQLKAELKNVQNIFSVERLDYSKGLPERFLAYEALLEKYPQHHGKIRYTQIAPTSRGDVQAYQDIRHQLENEAGRINGKYGQLGWTPLYYLNQHFDRKLLMKIFRYSDVGLVTPLRDGMNLVAKEYVAAQDPANPGVLVLSQFAGAANELTSALIVNPYDRDEVAAALDRALTMSLAERISRHAEMLDVIVKNDINHWQECFISDLK-----------------------

General information: TITO was launched using: RESULT: Template: 2WTX.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain C - contact count / total energy / energy per contact / energy per residue : 2345 -268798 -114.63 -617.93 target 2D structure prediction score : 0.61 Monomeric hydrophicity matching model chain C : 0.80 3D Compatibility (PKB) : -114.63 2D Compatibility (Sec. Struct. Predict.) : 0.61 1D Compatibility (Hydrophobicity) : 0.80 QMean score : 0.549

(partial model without unconserved sides chains): PDB file : Tito_2WTX.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2WTX-query.scw PDB file : Tito_Scwrl_2WTX.pdb: