Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence --------MTAMLPEWTTACPDWEERIVAKKSLMPCEPLFPQVADVAERIFKELILV-DVMGSPKMGDVTLDWVIEFVRAIFGSYNPNTKRRLIREFFLLISKKNTKSTIAAGVMLVALLLNDRLSAELIILAPTKEVADNSFNP----------IRDFIRADEELSAMINVSEHTKTVTHLG-TGATLKVIAAESNAAAGKKASIILID-EVWLFGKRANAESMFREAKGGLASRPEGCVIYLSTMSDEVPCGVFKQLLDYARDV-----R-DGIKEDKGFLPLIYEFPKRLVEAGEHLKPEHFYITN-------------------PNLGASVDL-------EYLISEFKKVKD-AGEESLRDFLAKHLNIEIGMNLRANRWAGAE-YWNKQKHVFGLDQLIEQSDVITIGIDGGGLDDLLGYAVLGRLKKD-PRVWWLWNHAWANK----IALERRKENIPKYDD--FKL---EGSLTVVDRVGDDIDQL---------AAIAKKVYDSGKLNKI----------GLDPLGLGGLLDGLLEAGIPEESMFAVP-------------------QGYKLMSYILT--------TERKLAEGNLYHAGQQLMTWAAGNARVVMVGNGMRITKQ--ESGVGKIDPLIATF--------------------NAVALM-SMNPEPTNKEYNV-FFV 1YVU Chain:A ((4-706)) EALLNLYRIEYRPKDTTFTVFKPTHEIQKEKLNKVRWRVFLQTGLPTFRREDEFWCAGKVEKDTLYLTLSNGEIVELKRVGEEEFRGFQNERECQELFRDFLTKTKVKDKFISDFYKKFRDKITVQGKNRKIALIPEVNEKVLKSEEGYFLLHLDLKFRIQPFETLQTLLERNDFNPKRIRVKPIGIDFVGRVQDVFKAKEKGEEFFRLCME---RSTHKSSKKAWEELLKNRELREKAFLVVL-EKGYTYPATILKPVLTYERNEVADIVRMEPGKRLNLIRYILRRYVKALRDYGWYISPEEERAKGKLNFKDTVLDAKGKNTKVITNLRKFLELCRPFVKKDVLSVEIISVSVWRKEEFLKELINFLKNKGIKLKIKGKSLILAQTREEAKEKLIPVINKIKDVDLVIVFLE-----FLLYDFVKRELLKKMIPSQVILNRTLKNENLKFVLLNVAEQVLAKTGNIPYKLKEIEGKVDAF--VGIDISRITRDGKTVNAVAFTKIFNSKGELVRYYLTSYPAFGEKLTEKAIGDVFSLLEKLGFKKGSKIVVHRDGRLYRDEVAAFKKYGELYGYSLELLEIIKRNNPRFFSNEKFIKGYFYKLSEDSVILATYNQVYEGTHQPIKVRKVYGELPVEVLCSQILSLTLMNYSSFQPIKLPATVHYSDKITKLMLRGIEPIKKEGDIMYWL

General information: TITO was launched using: RESULT: Template: 1YVU.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2354 110788 47.06 202.54 target 2D structure prediction score : 0.45 Monomeric hydrophicity matching model chain A : 0.64 3D Compatibility (PKB) : 47.06 2D Compatibility (Sec. Struct. Predict.) : 0.45 1D Compatibility (Hydrophobicity) : 0.64 QMean score : 0.188

(partial model without unconserved sides chains): PDB file : Tito_1YVU.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1YVU-query.scw PDB file : Tito_Scwrl_1YVU.pdb: