Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MRAKRPLRKSGPCFDLAGLMDHAAPELQVQQKNEQELNKFFIDVDDNTVSPMITTGPSFCATNTAGLSSNNSTVELTAREMAGTGSSASVEKRTMVSSQNEAKFIHVNDTNIFVLIDGISMFVEGKSTFTGTEDARLLVERLRQKKLARSVDTVQEAILNIQMSADHCDRKETAPVVSAVPSGSPVVPAEASPRQSTANTLPTSVPPLQSAVAPTALPVPLPPPQPVPIANPWASLFEDAKVPSGSPLFRSFKAKSLGSTSSHGFPPVHSTLLCESAETGATPSSPATTISPVTVTTPTSALSPTTGFNASSRLTHSVSFPSLRHQDSSSSLLSATSGAGHRHGGHASRGAAARRTKQISAEEIGHSNCSLDMDEVAVEAMIGKGTQGTVFRVRL--DGKLYALKCMNIDEAMNATNDVERQGYKKGLVKELTMITLQRSRPSPAYLMQMFNAVASLDAEKKQLSILMELMSFTVENIQQMVSRIPSEELMRVTQSTFRNYMSGDPSAKQSMKECCKDQLLYGSPRHALGRSTYKEPAAWEKNVKRETPMPEVLLSMLARDVLMGLNELHTDYSIIHCDLKPANVMLCYDQQKFKLADFGCGSVMEDHQHVERRGIDLGTILYKAPERFVANILHRIADIDDGGTGEAVVFTAKADVWSLGIMLMELAAGIHPCDQFKSDFWNYSTMLKL-SKMV--KPLNWSESFYDFILRSVCVDVSLRWSVQQLLKHPFIIKFNHVPREKLKLFVQRLEADSKTFHKRQQSELLKEQILLSTTRRHKDTFQLQSRKVWSTYTAYLKQAPPTKDQTMFPELRHT 2Y7J Chain:C ((93-364)) ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLS--PEQLEEVREATRRETHILRQVAG-H-P-HIITLIDSYE----SSSFMFLVFDLMRKG-------------------------------------------------ELFDYLTE---------------KVALSEKETRSIMRSLLEAVSFLHAN-NIVHRDLKPENILLDDN-MQIRLSDFGFSCHLEPGE---KLRELCGTPGYLAPEILKCSM-----------DETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL-MLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFE----------------------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 2Y7J.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain C - contact count / total energy / energy per contact / energy per residue : 1259 -31836 -25.29 -119.23 target 2D structure prediction score : 0.56 Monomeric hydrophicity matching model chain C : 0.60 3D Compatibility (PKB) : -25.29 2D Compatibility (Sec. Struct. Predict.) : 0.56 1D Compatibility (Hydrophobicity) : 0.60 QMean score : 0.358

(partial model without unconserved sides chains): PDB file : Tito_2Y7J.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2Y7J-query.scw PDB file : Tito_Scwrl_2Y7J.pdb: