Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MVSTIGIVSLSSGIIGEDFVKHEVDLGIQRLKDLGLNPIFLPHSLKGLDFIKDHPEARAEDLIHAFSDDSIDMILCAIGGDDTYRLLPYLFENDQLQKVIKQKIFLGFSDTTMNHLML-HKLGIKTFYGQSFLADICELDKEMLAYSLHYFKELIETGRISEIRPSDVWYEERTDFSPTALGTPRVSHTNTGFDLLQGSAQFEGKILGGCLESLYDIFDNSRYADSTELCQKYKLFPDLSDWEGKILLLETSEEKSKPEDFKKMLLTLKDTGIFAVINGLLVGKPMDET--FHDDYKEALLDII-DSNIPIVYNLNVGHATPRAIVPFGVHAHVDAQEQVIRFDYNK 4H1H Chain:A ((11-320)) QGDEIRIIAPSRSIGIM--ADNQVEIAVNRLTDMGFKVTFGEHVAEMDCMMSSSIRSRVADIHEAFNDSSVKAILTVIGGFNSNQLLPYLD-YDLIS--ENPKILCGFSDITALATAIYTQTELITYSGAHFSSFSMEKG---LDYVMESFSDCLLQKEPFALKESATWSDDE--WYLDQE--NRNFIPNEGLVVMQP-GVAEGIIIGGNLCTLNLLQ-GTEY----------M--PN---LAGTILFIEDDFMT-IPETFDRDLESLLSQPGADEIEGMVIGRFQQKTAMTAEKLAYIIETKTALQKIPVISGADFGHTQPIATFPIGGTARIDTNQTD-------

General information: TITO was launched using: RESULT: Template: 4H1H.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1794 -67674 -37.72 -221.16 target 2D structure prediction score : 0.60 Monomeric hydrophicity matching model chain A : 0.69 3D Compatibility (PKB) : -37.72 2D Compatibility (Sec. Struct. Predict.) : 0.60 1D Compatibility (Hydrophobicity) : 0.69 QMean score : 0.515

(partial model without unconserved sides chains): PDB file : Tito_4H1H.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4H1H-query.scw PDB file : Tito_Scwrl_4H1H.pdb: