Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MFLAEFNQAPPDQL-KTLLNNCVHIPVWAEKIISERPYSSTSVLLGYAEQLSHTWSWQEIQAALATHPKIGERQAKKQLNAKEQNFSAQEQAGISL--DEQTQQALLQGNIEYEQKFGFIFLIKAAGLSSDEILKKLHQRLQNNLAIEKVIVHEQLAAIALLRLSQEVQA 2Q37 Chain:A ((26-179)) --------------GEDEWKVCCGSSEFAKQMSTSGPLTSQEAIYTARDIWFNQVNVTDWLEAFSAHPQIGNTP--------------SEQSTAFATTSASALQELAEWNVLYKKKFGFIFIICASGRTHAEMLHALKERYENRPIVELEIAAMEQMKITELRMAKLFS-

General information: TITO was launched using: RESULT: Template: 2Q37.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 559 4046 7.24 29.32 target 2D structure prediction score : 0.70 Monomeric hydrophicity matching model chain A : 0.72 3D Compatibility (PKB) : 7.24 2D Compatibility (Sec. Struct. Predict.) : 0.70 1D Compatibility (Hydrophobicity) : 0.72 QMean score : 0.550

(partial model without unconserved sides chains): PDB file : Tito_2Q37.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2Q37-query.scw PDB file : Tito_Scwrl_2Q37.pdb: