Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKLTVFCGSRFGNKESYKFIAQTLGKYMAQEEIELVYGGSYSGIMGVISKTVLENNGKVTGIYPNGLFETELPGKDVTTFIPTETIDERKVLLFEKGDAVLVFPGGLGTLEEFSQLLSWIAIGLTPDKPIGILNIGGYYSGLQQLLETFAKEDFMDKKWLDQVIFSNNPLELVNELRAVSIKNQLLLKEAK 1WEK Chain:D ((38-215)) PLVSVFGSARFGEGHPAYEAGYRLGRALAEAGFGVVTGGGP-GVMEAVNRGAYEAGGVSVGLNIELP------NPYQTHALSLRYFFVRKVLFVRYAVGFVFLPGGFGTLDELSEVLVLLQTEKVHRFPVFLLDR-GYWEGLVRWLAFLRDQKAVGPEDLQLFRLTDEPEEVVQALKAEAP----------

General information: TITO was launched using: RESULT: Template: 1WEK.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain D - contact count / total energy / energy per contact / energy per residue : 925 -124695 -134.81 -720.78 target 2D structure prediction score : 0.72 Monomeric hydrophicity matching model chain D : 0.74 3D Compatibility (PKB) : -134.81 2D Compatibility (Sec. Struct. Predict.) : 0.72 1D Compatibility (Hydrophobicity) : 0.74 QMean score : 0.494

(partial model without unconserved sides chains): PDB file : Tito_1WEK.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1WEK-query.scw PDB file : Tito_Scwrl_1WEK.pdb: