Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MAQTLCGCPFAEVMCPVLVMESSRARIAAAAIRNPDPASSSAMTVDPDTQRQGLPLTLGRPPHSGSSSSSLRHLDSPQPLASNATVLDRKEDDMAEDSRGTYHQAAAAAANGDASDAGVDDEGGPETNSAPASRILKSISKTLMGRASSSSHNTTTNAVTMATSTAATATGTFTPNHSALPLEKLNSDSPTPPPPCAWSLVYANDAAASMLGCSSVDEVTTAAFDNLLCCFALTLPPSASAGSVRSSMPLVTAAAATDGASVPFALASLPATASSSSPQAACFGEKEMASNDENDDKGRQKHQQPSSNAVQQPGWREVQNPGELFALPNHNYVILYSKRTSAYYAALAVPSHQPKMSQRTSVDGESTPRMGSPSTMRNQSLCPTIQQAECYPPVPRNPSHPSADVPSSRLTGSEEATGMAQCGRRTSTILAAANTSSPFEPDLSDGASPPPPMQQQRCSRYVEIYILQRLESSHRPAGIARMPTARAVAAGPPPTLVTLGSGAADARGPGARTATSPGDHRSTAVFTPPPAEAPHLRSPQQLPPPPHRPPRSALSNSATAAAVTETGSVDSLDVDAPRPLREQYANRSQHASLHPMVQSQRRLPSSSTERSSNWAASRTSGHPGSPAPGVQVTFGSPETPSANSDAASAMRSSSQHTNQNSLYDLSYPAFHVNLAQPTITSTDCLYGANEPAGAAPLAAAVAGGSRGLPLTPLHKPGEDPHHNYSSPNSSSTPLQKTASNARQPQPEQRHLLSRQRQHRPLAGLVDDEDEARAVTRFKRSSMNNSLPISPALQPASGPASRQRSLSSAPLSATSTTIALLSCARSRMLSPLYQQLPPPSSGRVSSSGSARLQSPAASTAALAPAVTPPAPRRAMQEARDVESVVQLAQQVRAEQQPYRKNKAGQLVAFARGSPPSAWAHRDSQPLSPLSLSLFHSHASLVHRSPHSGGHHSLVSGGDAAGLSEYSLPHHTFPSAVTGCLLQQPQPSGWASPMETSAAQMLGNVAGMSWQRSNEVDQITPHKLADRVRSQRGVVAVLVSARLPHTIIFNSVAFMMFVQHVLRFQRRNGATQVACILNVCRKMQLVIHMIPVEVLPGASGCVKRTGADNGSPSTNSASPASRRVSVSWKANNGNAEGADGNSSTVTEAVWALSKLNATLPSPHEANPAGHHLLGSLPSSAPATSSQQQQRMIVELLRARLEDLDVLYGYEELMEAFSPAAPALDSSVRGFIPSHSSSGSGPFTNSNSSCAPPTATASSLGTGIVASSPPWGSMQHYSTQASPLHSPSGGSKESRTATPQRSVQSLLATNAVPRHPHRDPLRCSRAWSCSPHLQQQAHDRNASTTPSVTAVQKVALVSNAASSGGDRRDSRRRSTSGNLGTCSGTDRLSKRSSAMRSSGDSVSNGALSRRSSFMTRTTAATAATAAAAAAAAAAAVRAADSVQRKGSFAMLSGAAAHAADGSRAASVVLSRASNPASTTASGTADAAREGGNSSILTSNTTAASHTFDPAFSEVRALGMQQNTGEEGDDTLSRQRTRMENGESSDEVIETAAESSPTSLPSRRTGSVKQSLLWAYPGAGSASQAPQPQHRRLPPRYVSSSSYLSRDMRESLAMCDAATRIRADTYEARVLIPFTTPQRLELLSRLGNVQLSKYRGLSVFGVNLVNLVTEEAAAEAAQPSPPIIPLRYDIAARTYLEGVRGKSVIFSPLMSPTTAAPSFPSKSARASADVKEAKAEPTEAESAVANTAAAKMSSADTLSEAAAPAAGAAVSMALRLRPPPLQALASSAAGAPGIAVPVVSAVTSATMSSLSARSRGESSAFSSGAAGQKVAPLEAANPSGFSTTQHGSASGSEGTSPEGVDDDTLRRGSGATASGEATPTQRHADPFQLPMDSSPTGGTHHGTYRGLLTLSMKSKDDGEDGHFSASVVAATAAHAEAAKGMEDGKKRISDNVGRCAKQLHEGRTLRAAASFSVLTVSSGSLPRKGTGLQLPAVLLDGTIAAAEGKSRSTAVAKTEKEQLTAHARTTTQRASMEITSPLRRGSRDAAPVGETRSTANTAVTVSTAVMRSPPQRHGPQRNLTPHSCHHAVELSAQSGTLQTPLHVALPFAESWSAGLQSPPVSQGSNILSASCAAGVSGASITADSSADRTTRSSRSGTPSTQSRPSVPYPSSLPHPIVSCTAPFAAGNNNPTEPASTQSSKTQGLVSVCTQKSGGTELLGYALSNSAAAAFGDLSTALKKEDNEHAGSSARASSTENKEEAKKATVNATALLEPLAVGAPETKRHTQQYANPASLSGQAPESVIVADISAHAALPSISFATLTGTAAAQSTTAEEGDAMTSTMEVKLSGVSADNGEHKSSGNLGNLVAPVATGNGGAGASDDRRAPAGGGNANMPDEANDSFADSFMDIFGLVNRPQQLADLRRCVSMHVRSVCDHGFLSTGSSSMSSGATTNAVAAAAAVQGNTSSSSTGNRGWGAAVAAQPIRPLTAFVSSPSESRVDEGVRSSESSKLRRIAGLSNIAATAEKGATPYENAAMRAVAEDAADQTTRNNLHVLVYTTRAYAEVEEVLGIYGHCTTFVTSATKMLRYARSGLQLFDVVIVEWVESLISGEMHDTLAKHAVEETVVAFFISTRPGVRTPTMNVDNIMTDATVVMYADNLLEGLLSRNVLEEVQQLIRRRRLLRSMVGVRKEQSYQIVSHIGSGAFGDVFEVMMYVSRGRLAMKRIFLKSMK---LRQLEIINREVSIMRSLEHPNIVSFSHTRLEDNAYAIFMELCDATLANHLLEPSVAIPGAAQRQQYRSAGLMAGYPDNAMNNSSNSVSGNGVDVAGMLQAAAREGGRTEFPGAHGASIMTPELKRPQDAVMIVHDIASALIYLHRRGIIHRDIKPANVLFAN----GMAKLGDFGSAVKMTESR-QLRNMKGTVSYMAPEMVLGEPYTESCDLWSFGCLIARIMGINLGHLNGLHMPALNELYRAIPKTGSLPLTFTNRLSSRFGHHFTEETTSRVLKALKHAIEIDMAERQLAASPNSHNSVDANSTVEDKEMQSSSQQTTSIGSDASLCTDTASMTSERESRHATEPDGTGTATSEADTQNSRRSILCITTSDIVVLGEFFVLLPASLVDLFNRLFHRDPAKRMTAAEVLDHQVSWDVEWMARMMQEIYEVSCLIEQRSAGAQGAAGGASRFHLAGQAGGGRLPRGEEGAGTGVATPSMTAGNFAHFPIQPGSGELAWMTGGSGGQRVLGAAGTGSGANILSAANNYVLDLSLSSSSSGSGGRGSKDEASDD 3C0G Chain:B ((22-231)) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRAD------------------------------------------------A---------------GFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 3C0G.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain B - contact count / total energy / energy per contact / energy per residue : 912 -39933 -43.79 -197.69 target 2D structure prediction score : 0.48 Monomeric hydrophicity matching model chain B : 0.54 3D Compatibility (PKB) : -43.79 2D Compatibility (Sec. Struct. Predict.) : 0.48 1D Compatibility (Hydrophobicity) : 0.54 QMean score : 0.303

(partial model without unconserved sides chains): PDB file : Tito_3C0G.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3C0G-query.scw PDB file : Tito_Scwrl_3C0G.pdb: