Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTDSQQSKPKHVMMMAAGTGGHVFPALAVAKQLQQQGCQVSWLATPIGMENRLLKDQNIPIYQIDIQGVRG--NGVIRKLA-APFKILKA-TFSAMRYMKQLKVDAVAGFGGYVA-GPGGLAARLLGIPVLIHEQNAVAGF----------------------T---NAQLSRVA-----------------KVVCEAFPNTFP---A-SEKVVTTGNPVRREITDILSPKWRYDEREQAGKPLNILIVGGSLGA-KALNERLPPALKQLQVPLNIFHQCGQQQVEATQALYADAPANLTVQVLPFIEDMAKAYSEADLIICRAGALTVTEVATAGVAAVFVPLPIAVDDHQTANAKFLADVGAAKICQQSTMTPEVLNQLFTTLMNRQLLTEMAVKARQHAQPNATQHVVGLIQKM 1IIR Chain:A ((1-395)) ---------MRVLLATCGSRGDTEPLVALAVRVRDLGADVRMCAPPDC-AE-RLAEVGVPHVPVGP----RAKPLTAEDVRRFTTEAIATQFDEIPAAAE--GCAAVVTTGLLAAAIGVRSVAEKLGIPYFYAFHCPSYVPSPYYPPPPIDIPAQWERNNQSAYQRYGGLLNSHRDAIGLPPVEDIFTFGYTDHPWVAADPVLAPLQPTDLDAVQTGAWILPDERPLS-P-ELAAF--LDAGPPPVYLGFG--APADAVRVAI-DAIRAH--GRRVILSRGWAD-L-VL---PDDGAD--CFAIGEV-NHQVLFGRVAAVIHHGGAGTTHVAARAGAPQILLPQMA----DQPYYAGRVAELGVGVAHDGPIPTFDSLSAALATALTPETHARATAVAGTIRT-DGAAVAARLLL--

General information: TITO was launched using: RESULT: Template: 1IIR.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1638 -74279 -45.35 -229.25 target 2D structure prediction score : 0.61 Monomeric hydrophicity matching model chain A : 0.64 3D Compatibility (PKB) : -45.35 2D Compatibility (Sec. Struct. Predict.) : 0.61 1D Compatibility (Hydrophobicity) : 0.64 QMean score : 0.459

(partial model without unconserved sides chains): PDB file : Tito_1IIR.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1IIR-query.scw PDB file : Tito_Scwrl_1IIR.pdb: