Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence -ECWVELFGPGKVSHGKQTGRWNAPYYFNLD-P-MRLIYLHENCKVNEKHTVLLPDNVKWDV-ETGMIS------ 1LW6 Chain:I ((2-64)) KTEWPELVG---KS-VEE-----AKKVILQDKPAAQIIVLPVGTIVTM---EYRIDRVRLFVDKLDNIAQVPRVG

General information: TITO was launched using: RESULT: Template: 1LW6.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain I - contact count / total energy / energy per contact / energy per residue : 129 -5681 -44.03 -107.18 target 2D structure prediction score : 0.47 Monomeric hydrophicity matching model chain I : 0.68 3D Compatibility (PKB) : -44.03 2D Compatibility (Sec. Struct. Predict.) : 0.47 1D Compatibility (Hydrophobicity) : 0.68 QMean score : 0.249

(partial model without unconserved sides chains): PDB file : Tito_1LW6.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1LW6-query.scw PDB file : Tito_Scwrl_1LW6.pdb: