Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKAIITVVGKDKSGIVAGVSGKIAELGLNIDDISQTVL---DEYFTMMAVVSSDEK-QDFTYLRNEFEA-FGQTLNVKINIQSAAIFEAMYNI 3W7B Chain:A ((3-86)) -EARLLVTCPDRPGIVAAVSGFLYAHGANITDLQQHSTDPEGGTFFMRVAFTASHLDLARPALERAFQEVVASRFQMQWRLAYAS--------

General information: TITO was launched using: RESULT: Template: 3W7B.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 286 -22069 -77.16 -279.35 target 2D structure prediction score : 0.46 Monomeric hydrophicity matching model chain A : 0.70 3D Compatibility (PKB) : -77.16 2D Compatibility (Sec. Struct. Predict.) : 0.46 1D Compatibility (Hydrophobicity) : 0.70 QMean score : 0.516

(partial model without unconserved sides chains): PDB file : Tito_3W7B.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3W7B-query.scw PDB file : Tito_Scwrl_3W7B.pdb: