Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTTPLNERRIANAIRVLAMDAVQQANSGHPGAPMGMADIADVVWREFLNHNPN-NPQWANRDRFVLSNGHGSMLQYALLHLTGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGIETTTGPLGQGIANAVGFALAEKTLAAQFNKDDLKVVDHFTYCFLGDGCLMEGISHEVCSLAGTLQLGKLIAYYDDNGISIDGEVEGWFSDDTEERFKSYGWQVLRV-DGHDADAIRQATVEAKAETQKPTIIICKTIIGLGSPNKQGKEDCHGAPLGKDEITLTREALGWTEEAFVIPADVYAAWDA--KAKGNEAEAAWNEVFAQYQAKYPTEAAELLRRISGDLPTEFSAQADAFIRETNAKAETVATRKASQNTLQAFGPLLPELLGGSADLAGSNLTLWKGCQGVQ-ENPAGNYVYYGVREFGMTAIANGVALHGGFIPYAATFLMFMEYARNAVRMSALMKQRVIHVYTHDSIGLGEDGPTHQPIEQIASLRGTPNLNTWRPADTVETAIAWKSALERKDGPTALIFSRQNLPFQTRTEEQIQNAA-KGGYILAQEKGELKAIIIATGSEVSLAMEAYAQLE----GVRVVSMPCAEEFMKQDAAYREAVLPAHIRARVAVEAAHVDYWWKFVGLDGKVIGMTTYGESAPAKDLFQFFGITTEAVVAAVKELTA 4C7X Chain:A ((29-675)) -----------NTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPKTHMNWVNRDRFVLSAGHGSALLYSLAHLAGYDVSMDDLKNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLMEGVASEAASLAGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVEDGFNLEEIDKAIVQAKAESDKPTIIEIKTTIGYGSEN-QGTHKVHGSPLGEEGVAHAKEVYNWNYPPFTVPEEVSQRFKECLQDKGVKAENKWNEMFEAYKKEYSDLAQKFSDGFSNKVPNTLGD-----ILPQYGEDDSIATRAASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGDFQPESYEGRNIWFGVREFGMACAMNGIMLHGGTRIFGSTFFVFSDYLKAAIRLSAIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLASLRTIPNVQVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPISKEKVFDGVEKGGYVVQGAENEADGILIATGSEVGLALKAKEELQKKGKDVIVVSLPSWERFEAQSEEYKNTVIPPELKKRMTIEAGTTYGWAKYAGDHGVMIGIDEFGMSAPSDIVLRELGMSVENIV--------

General information: TITO was launched using: RESULT: Template: 4C7X.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 4113 55202 13.42 86.66 target 2D structure prediction score : 0.69 Monomeric hydrophicity matching model chain A : 0.84 3D Compatibility (PKB) : 13.42 2D Compatibility (Sec. Struct. Predict.) : 0.69 1D Compatibility (Hydrophobicity) : 0.84 QMean score : 0.515

(partial model without unconserved sides chains): PDB file : Tito_4C7X.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4C7X-query.scw PDB file : Tito_Scwrl_4C7X.pdb: