Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTIFETVVTDVGIEAEVFRKEKIMILFGDEA------PETLTDYCYKIELNQV-RKEITCDMKLCFD---KQMYVITAVGDVVQTNLNELGHITIKFDGSHEP-ELPGTMYVEDKEMPHLRKGTIIKIDQEDQNGGKLYGNHA 2XDP Chain:A ((22-120)) --YYSCRVMAVTS------QTFYEVMFDDGSFSRDTFPEDIVSR------DCLKLGPPAEGEVVQVKWPDGKLYGAKYFG--SNI----AHMYQVEFEDGSQIAMKREDIYTLDEELPK------------------------

General information: TITO was launched using: RESULT: Template: 2XDP.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 331 -6241 -18.85 -70.91 target 2D structure prediction score : 0.57 Monomeric hydrophicity matching model chain A : 0.64 3D Compatibility (PKB) : -18.85 2D Compatibility (Sec. Struct. Predict.) : 0.57 1D Compatibility (Hydrophobicity) : 0.64 QMean score : 0.370

(partial model without unconserved sides chains): PDB file : Tito_2XDP.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2XDP-query.scw PDB file : Tito_Scwrl_2XDP.pdb: