Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDF------------CHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQR--NTETPFLLVLSYLHVHTALF-SSKDFAG----------------------------KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMP-LLEGKSQR-SDHEFLFHYCNA---YLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR 2QZU Chain:A ((20-475)) ------------------QAQEKQPTPNLVFIMADQYRGDAIGCIGKEPVKTPHLDKLASEGINFTNAISSYPVSSPARGMLMTGMYPIGSKVTGNCNSETA---PYGVELSQNARCWSDVLKDQGYNMGYIGKWHLDAPYKPYVDTYNNRGKVAWNEWCPPERRHGFDHWIAYGTYDY---HL-----------KP------------------------------------------MYWNTT----------APRD----SFYYVNQWGPEYEASKAIEYINGQKDQKQPFALVVSMNPPHTGYELVPDRYKEIYKDLDVEALCKGRPDIPAKGTEMGDYFRNNIRNYYACITGVDENVGRIIEALKQNNLFDNTIVVFTSDHGICMGAHEN-------------AGKDIFYEESMRIPMILSWPDQIKPRKSDPLMIAFADLYPTLLSMMGFSKEIPETVQTFDLSNEVLTGKNKKDLVQPYYFVKFDNHATGYRGL------RTDRYTYAVHAT----------------------DGKIDNVILFDRTNDPHEMNNIASQQLKLTHTFNRQLKTWLEKTNDP-------------------------------------------

General information: TITO was launched using: RESULT: Template: 2QZU.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2545 -7581 -2.98 -18.58 target 2D structure prediction score : 0.63 Monomeric hydrophicity matching model chain A : 0.65 3D Compatibility (PKB) : -2.98 2D Compatibility (Sec. Struct. Predict.) : 0.63 1D Compatibility (Hydrophobicity) : 0.65 QMean score : 0.443

(partial model without unconserved sides chains): PDB file : Tito_2QZU.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2QZU-query.scw PDB file : Tito_Scwrl_2QZU.pdb: