Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKIRIDIPHHPYDIQIEKGCMAQAGQWLRELWQPQKVVIVTDNHVASLYAEKVKLSLEDAGFQVAVFDFLEGEERKNLTTVQKVYEFLVKQGLTRSDGIVALGGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQVDSSIGGKTGVNTPFAKNMVGTFAQPDGVLIDPLVLETLGKRELIEGMGEVIKYGLIEDPELWALLTGLNGSVE--SILEHAETLIEHSCQVKRKMVVEDELDNGIRLYLNFGHTIGHAIEATAGYGKVMHGEAVAMGMVQISKIAEEKGLMPAGITQSITEMCQKFGLPVDYENWEVDKLYQALTHDKKARGNTLKLVLVPELGSATIHPVSLEEMKDYLVK 1XAH Chain:B ((1-347)) MKLQTTYPSNNYPIYVEHGAIKYIGTYLNQ---FDQSFLLIDEYVNQYFANKFD------N--VHKVIIPAGEKTKTFEQYQETLEYILSHHVTRNTAIIAVGGGATGDFAGFVAATLLRGVHFIQVPTTILAH-DSSVGGKVGINSKQGKNLIGAFYRPTAVIYDLDFLKTLPFKQILSGYAEVYKHALLNGESATQDIEQHFKDREILQSLNGMDKYIAKGIETKLDIVVADEKEQGVRKFLNLGHTFGHAVEYY--HK-IPHGHAVMVGIIYQFIVANALFD-SKHDISHYIQYLIQLGYPLD-------TLYQYML--------GVQMVLMRQFGDIVVQHVDQLTLQHACE-

General information: TITO was launched using: RESULT: Template: 1XAH.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain B - contact count / total energy / energy per contact / energy per residue : 1765 -130201 -73.77 -403.10 target 2D structure prediction score : 0.61 Monomeric hydrophicity matching model chain B : 0.77 3D Compatibility (PKB) : -73.77 2D Compatibility (Sec. Struct. Predict.) : 0.61 1D Compatibility (Hydrophobicity) : 0.77 QMean score : 0.542

(partial model without unconserved sides chains): PDB file : Tito_1XAH.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1XAH-query.scw PDB file : Tito_Scwrl_1XAH.pdb: