Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKNQLRIIGGEWKRRVLPFASIEGLRPTPDRVRETLFNWLMWNIQNAHVLDICTGSGALGFEALSRG-AASVYMIEPDKTQARFLKDNIQLLK---AHNCHLINATAQQALPRLKEQFDVVFLDPPYSLNL---WQELAHLADSHIKNNGYIYVEADRNLSELHLPATWQQIKSTKAGTVHAGLYQKVSE 4DCM Chain:A ((210-340)) -------------------------------GARFFMQHLPE-NLEGEIVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNMPEALDRCEFMINNALSGVE--PFRFNAVLCNPPF----DNVAWEMFHHARRCLKINGELYIVANRHLDY----------------------------

General information: TITO was launched using: RESULT: Template: 4DCM.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 592 -33317 -56.28 -284.76 target 2D structure prediction score : 0.67 Monomeric hydrophicity matching model chain A : 0.64 3D Compatibility (PKB) : -56.28 2D Compatibility (Sec. Struct. Predict.) : 0.67 1D Compatibility (Hydrophobicity) : 0.64 QMean score : 0.710

(partial model without unconserved sides chains): PDB file : Tito_4DCM.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4DCM-query.scw PDB file : Tito_Scwrl_4DCM.pdb: