Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MQLLQQIHGLRGTVRIPADKSISHRSIMFGAIAEGTTTIQNFLRAEDCLSTLHAFQQLGVEIEEEE--EVIKIHGRGSHSFVQPTESIDMGNSGTTIRLLMGILAGQPFTTTLFGDASLSKRPMGRVMEPLREMGADLQGEENDQYLPITVTGTRSLSPIRYNMPVASAQVKSALLFAALQAEGTSVIVEKERSRNHTEEMIRQFGGRITVEDKTIIVTGPQKLTGQQITVPGDISSAAFFLAAGLLVPESQLLLKNVGVNPTRTGILDVLEEMGAAITQTNHNE--QNQSADLSVKTSHLKKATIGGEIIPRLIDELPILALVATQAEGITIIKDAEELKVKETNRIDAVAEELQKMGAKIKATADGLIIHGPTPLHGAKVSSRGDHRIGMMLQVAALIADGPCELEGAEAVSISYPAFFDDLAELVSGGEAHG 3SLH Chain:D ((8-435)) ---TIPSQGLSGEICVPGDKSISHRAVLLAAIAEGQTQVDGFLMGADNLAMVSALQQMGASIQVIEDENILVVEGVGMTGLQAPPEALDCGNSGTAIRLLSGLLAGQPFNTVLTGDSSLQRRPMKRIIDPLTLMGAKIDST--GNVPPLKIYGNPRLTGIHYQLPMASAQVKSCLLLAGLYARGKTCITEPAPSRDHTERLLKHFHYTLQKDKQSICVSGGGKLKANDISIPGDISSAAFFIVAATITPGSAIRLCRVGVNPTRLGVINLLKMMGADIEVTHYTEKNEEPTADITVRHARLKGIDIPPDQVPLTIDEFPVLLIAAAVAQGKTVLRDAAELRVKETDRIAAMVDGLQKLGIAAESLPDGVIIQGGT-LEGGEVNSYDDHRIAMAFAVAGTLAKGPVRIRNCDNVKTSFPNFVELANEVGMNVKGV-

General information: TITO was launched using: RESULT: Template: 3SLH.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain D - contact count / total energy / energy per contact / energy per residue : 2854 -42164 -14.77 -99.44 target 2D structure prediction score : 0.58 Monomeric hydrophicity matching model chain D : 0.84 3D Compatibility (PKB) : -14.77 2D Compatibility (Sec. Struct. Predict.) : 0.58 1D Compatibility (Hydrophobicity) : 0.84 QMean score : 0.556

(partial model without unconserved sides chains): PDB file : Tito_3SLH.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3SLH-query.scw PDB file : Tito_Scwrl_3SLH.pdb: